John G F Cleland Selected Research

Carvedilol (Coreg)

12/2018	Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin.
9/2017	Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure.
2/2010	Effects of carvedilol or metoprolol on PAI-1, tPA-mass concentration or Von Willebrand factor in chronic heart failure--a COMET substudy.
2/2010	Clinical trials update from the American Heart Association meeting 2009: HEAAL, FAIR-HF, J-CHF, HeartMate II, PACE and a meta-analysis of dose-ranging studies of beta-blockers in heart failure.
8/2009	Clinical trials update from the European Society of Cardiology Heart Failure meeting 2009: CHANCE, B-Convinced, CHAT, CIBIS-ELD, and Signal-HF.
8/2007	Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol Or Metoprolol European Trial (COMET).
8/2007	Prognostic importance of plasma NT-pro BNP in chronic heart failure in patients treated with a beta-blocker: results from the Carvedilol Or Metoprolol European Trial (COMET) trial.
6/2007	The safety of amiodarone in patients with heart failure.
3/2007	Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
5/2006	Clinical trials update from the American College of Cardiology: Darbepoetin alfa, ASTEROID, UNIVERSE, paediatric carvedilol, UNLOAD and ICELAND.

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John G F Cleland Research Topics

Disease

290	Heart Failure 05/2022 - 01/2002
44	Left Ventricular Dysfunction 01/2022 - 01/2002
30	Atrial Fibrillation 06/2022 - 06/2003
27	Myocardial Infarction 01/2022 - 10/2003
23	Stroke (Strokes) 01/2021 - 01/2005
21	Coronary Artery Disease (Coronary Atherosclerosis) 12/2021 - 10/2003
17	Dyspnea (Shortness of Breath) 05/2022 - 07/2005
14	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 05/2022 - 06/2007
11	Sudden Death 01/2017 - 01/2002
10	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2002
10	Inflammation (Inflammations) 01/2022 - 12/2013
9	Fibrosis (Cirrhosis) 01/2022 - 01/2012
9	Systolic Heart Failure 01/2021 - 07/2003
7	Iron Deficiencies 01/2022 - 02/2010
7	Heart Diseases (Heart Disease) 01/2022 - 10/2006
7	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2022 - 08/2007
7	Type 2 Diabetes Mellitus (MODY) 11/2021 - 01/2006
7	Coronary Disease (Coronary Heart Disease) 11/2021 - 01/2005
6	Cardiomyopathies (Cardiomyopathy) 01/2022 - 03/2007
6	Hemorrhage 01/2022 - 11/2013
6	Hypertension (High Blood Pressure) 01/2020 - 04/2013
5	Atherosclerosis 01/2020 - 01/2002
5	Cardiac Sudden Death (Sudden Cardiac Arrest) 07/2017 - 10/2007
5	Anemia 01/2016 - 05/2004
4	Chronic Obstructive Pulmonary Disease (COPD) 05/2022 - 03/2012
4	Neoplasms (Cancer) 01/2022 - 11/2013
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018 - 11/2009
4	Diastolic Heart Failure 06/2015 - 10/2006
3	Cardiac Arrhythmias (Arrythmia) 06/2022 - 01/2004
3	Weight Loss (Weight Reduction) 01/2022 - 12/2013
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2017
3	COVID-19 01/2022 - 01/2020
3	Pulmonary Hypertension 01/2022 - 09/2015
3	Diabetes Mellitus 01/2021 - 10/2015
3	Chronic Renal Insufficiency 01/2021 - 11/2010
3	Hypotension (Low Blood Pressure) 01/2016 - 01/2008
3	Stable Angina 04/2010 - 01/2002

Drug/Important Bio-Agent (IBA)

39	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 10/2003
36	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 02/2006
26	Biomarkers (Surrogate Marker)IBA 06/2022 - 09/2008
21	Carvedilol (Coreg)FDA LinkGeneric 12/2018 - 06/2002
20	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2022 - 01/2003
19	DiureticsIBA 05/2022 - 07/2003
19	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 01/2002
18	Natriuretic PeptidesIBA 05/2022 - 06/2008
17	Rosuvastatin Calcium (Crestor)FDA Link 01/2017 - 05/2006
15	Metoprolol (Toprol-XL)FDA LinkGeneric 09/2017 - 06/2002
14	CreatinineIBA 01/2022 - 05/2004
13	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2022 - 06/2005
13	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 03/2006
11	Mineralocorticoid Receptor AntagonistsIBA 01/2021 - 06/2003
11	rolofyllineIBA 11/2019 - 08/2006
10	RivaroxabanIBA 01/2021 - 04/2011
9	Warfarin (Coumadin)FDA LinkGeneric 11/2013 - 06/2004
8	Spironolactone (Aldactone)FDA LinkGeneric 01/2022 - 12/2005
8	Angiotensin Receptor AntagonistsIBA 01/2022 - 01/2004
7	GadoliniumIBA 12/2021 - 03/2012
7	IronIBA 08/2021 - 08/2006
7	omecamtiv mecarbilIBA 01/2021 - 11/2006
7	IvabradineIBA 03/2015 - 12/2008
6	Oxygen (Dioxygen)IBA 01/2022 - 10/2005
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2005
6	CholesterolIBA 01/2021 - 03/2007
6	Cardiac MyosinsIBA 01/2021 - 11/2006
6	Dobutamine FDA LinkGeneric 01/2020 - 05/2002
5	Urea (Carbamide)FDA LinkGeneric 01/2022 - 03/2006
5	Digoxin (Digitek)FDA LinkGeneric 01/2022 - 12/2003
5	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 01/2005
5	PotassiumIBA 01/2021 - 01/2005
5	Myosins (Myosin)IBA 12/2020 - 11/2006
5	C-Reactive ProteinIBA 01/2020 - 06/2007
5	tezosentanIBA 01/2017 - 08/2003
5	Simendan (Levosimendan)IBA 12/2008 - 05/2002
5	Darbepoetin alfa (Aranesp)FDA Link 09/2007 - 08/2005
4	Galectin 3 (LGALS3)IBA 01/2022 - 02/2010
4	sacubitril and valsartan sodium hydrate drug combinationIBA 11/2020 - 01/2017
4	Purinergic P1 Receptor AntagonistsIBA 11/2019 - 05/2011
4	Pharmaceutical PreparationsIBA 01/2016 - 12/2005
4	Hemoglobins (Hemoglobin)IBA 12/2013 - 08/2005
4	Perindopril FDA LinkGeneric 05/2012 - 10/2003
4	Adenosine (Adenocard)FDA LinkGeneric 03/2012 - 08/2006
4	Clopidogrel (Plavix)FDA Link 12/2009 - 06/2004
3	CollagenIBA 01/2022 - 01/2021
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 01/2013
3	Transferrin Receptors (Transferrin Receptor)IBA 01/2022 - 12/2013
3	Collagen Type I (Type I Collagen)IBA 01/2022 - 01/2012
3	SodiumIBA 11/2021 - 11/2009
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 11/2019 - 01/2003
3	Neprilysin (Neutral Endopeptidase)IBA 06/2019 - 01/2017
3	Enalapril FDA LinkGeneric 01/2018 - 10/2005
3	Bisoprolol (Concor)FDA LinkGeneric 09/2017 - 10/2005
3	Endothelin Receptors (Endothelin Receptor)IBA 01/2017 - 07/2005
3	HematinicsIBA 01/2016 - 05/2004

Therapy/Procedure

107	Therapeutics 05/2022 - 01/2002
27	Cardiac Resynchronization Therapy 01/2022 - 01/2002
12	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 10/2019 - 01/2002
9	Length of Stay 01/2022 - 10/2003
7	Patient Readmission 01/2020 - 03/2013
5	Secondary Prevention 01/2022 - 10/2003
5	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2019 - 05/2013